Logan UDT-850DLA 8-Vessel Dissolution Collection System
The Logan UDT 850-8 / SYSTEM 850DLA 8-vessel tablet dissolution analyzer is designed for routine dissolution analysis in pharmaceutical quality control (QC) and formulation research and development (R&D). It adopts a standard 8-tank layout (configurable with 6 sample test cups and 2 control/blank cups) and can efficiently complete dissolution and release assessments and curve comparison tests for various solid oral formulations under extremely uniform and precise temperature-controlled water bath flow conditions.
I. Fully compliant with the strict regulatory requirements of the United States Pharmacopeia (USP) <711/724>, the European Pharmacopoeia (EP), the British Pharmacopoeia (BP), the Japanese Pharmacopoeia (JP), and the Chinese Pharmacopoeia (ChP).
II. The instrument is equipped with an integrated, fully enclosed, anti-evaporation double-layer insulation module, a high-precision automatic positioning sampling and microporous filtration system, which can effectively prevent solvent evaporation and sample cross-contamination, greatly improve batch testing efficiency and ensure high reproducibility of dissolution analysis data.
III. The collection workstation is equipped with an independent multi-channel pipeline and a three-level access control mechanism, supporting up to 3 million unalterable audit trails.
IV. The rigidity architecture fully complies with FDA 21 CFR Part 11, strictly ensuring the authenticity, reliability, and data integrity of experimental data.
Equipment Introduction
Compliant with regulations and standards: 8-Vessel High-Efficiency Testing
Fully compliant with the United States Pharmacopeia (USP <711/724>), European Pharmacopoeia (EP), British Pharmacopoeia (BP), Japanese Pharmacopoeia (JP), and Chinese Pharmacopoeia (ChP), it features a standard configuration of 6 test sample tanks and 2 standard/blank control tanks, specifically designed for quality control (QC) and research and development (R&D) of solid formulations.
Precision Speed Control & High Concentricity Operation
It features a high-precision speed control system with a speed accuracy of ±1 RPM, and excellent concentricity and perpendicularity performance, ensuring that the flow field conditions in each tank are highly consistent and reproducible.
Fully Sealed & Dual-Layer Thermal Anti-Evaporation Design
It adopts a one-piece molded fully enclosed and double-layer heat-insulating low-evaporation module, which almost completely blocks the contact with the outside air and has a very small temperature difference (the actual temperature difference of 8 tanks is only within -0.1°C), effectively preventing solvent evaporation and fully complying with the stringent regulations.
Automated Positioning Sampling & Secondary In-Line Filtration
The sampling rack has an automatic positioning function, a fast sampling speed, and fully complies with the 2% sampling time error requirement of USP <711>.
Supports multiple specifications of secondary filter heads (regardless of brand), replacing tedious manual filtration; features an independent pipeline operation design, supporting automatic cleaning, dilution, reflux and constant temperature/room temperature replenishment, eliminating cross-contamination.
Data integrity and 21 CFR Part 11 compliance for the collector workstation.
It has a storage capacity of 3 million electronic audit trails, and the original files cannot be deleted or edited.
It supports 3-4 levels of user permission management and can create 100 sets of independent operator accounts and passwords.
High System Compatibility & Full Automation Integration
The machine has a compact structure that saves laboratory workspace; the system controller (DSC-800) is highly expandable and can simultaneously control up to 4 8-tank dissolution machines (no brand restrictions), and can also be connected in series with an MDS solvent preparation machine and an AVC automatic cleaning system to achieve a fully automated dissolution workflow.
Dedicated Apparatus 1/2 Storage Rack Design
It comes with a dedicated storage rack for the 1/2 section of the device, making it easy to quickly and easily secure the 1/2 section (Basket / Paddle) to the dedicated storage area, ensuring the device stays in place and effectively preventing damage from collisions.
Product Features
Fully enclosed to prevent evaporation; minimal temperature difference control.
Precise sampling; Highly efficient filtration.
Comprehensive audit follow-up; regulatory compliance; (21 CFR Part 11)
Overall Specifications
Vessel configuration : 8-Vessel (standard 6-vessel test vessel + 1 blank/standard sample vessel + 1 solvent replenishment vessel, also supports 8-cup full test vessel mode; fully compliant with ICH M9, USP, EP, JP and ChP standards)
Applicable vessel specifications : Standard configuration includes a 1000 mL one-piece seamless water bath (with patented double-walled anti-evaporation lids, compatible with USP Apparatus 1, 2, 5, and 6 methods; optional configurations include a 250 mL small-volume dissolution vessel or a 2000 mL / 4000 mL large-capacity dissolution bath).
Stirring speed range : 25 ~ 300 RPM (customizable) (speed accuracy ±1 RPM, resolution 0.1 RPM), supports 1-zone or 2-zone independent speed control function.
Temperature control accuracy : room temperature ~ 45.0°C, water bath temperature control accuracy ±0.1°C, temperature difference within each bath strictly controlled within 0.2°C, featuring low heat loss and protection against long-term medium volatilization.
Dosing and height positioning mechanism : Standard configuration includes an automatic dosing tray (Tablet Dropping Trays, supporting simultaneous and precise dosing in 8 slots), accurately corresponding to the specified heights (500 mL to 1000 mL) for the USP basket method, paddle method, rotary drum method, and disc method.
Sampling System and Pump Unit : Equipped with one SYP-8L-10 (SYP-8L2B-10ml) high-precision 8-channel syringe pump module (integrated into the DSC-800 system controller, saving desktop space), featuring a high-torque motor paired with an optical encoder closed-loop feedback control.
Sampling speed and cycle time : The entire channel synchronous sampling cycle is completed within 3 minutes (approximately 27.9 seconds for a 10 mL sample), meeting the USP <711> 2% sampling time error specification requirements.
Sampling volume range : 1.0 ~ 10.0 mL (maximum 10 mL per stroke; transmission accuracy better than ±0.05 mL when sampling volume > 1 mL, supports micro-sampling of 0.2 mL / 0.5 mL)
Filtration and flow path self-cleaning functions : compatible with 13 mm, 25 mm, and 38 mm syringe filters (small disc, 0.22 µm or 0.45 µm secondary filtration); features pre-wetting of the medium before sampling, isochoric and isothermal replenishment of the medium after sampling (maintaining sink condition), membrane backwashing, and fully automatic emptying and self-cleaning of tubing and syringes after testing.
Method storage capacity : The DSC-800 system controller has a built-in storage of up to 100 single-page test method protocols.
Number of sampling points : Up to 20 sampling time points can be set for a single method; supports pre-sampling alarm reminders and automatic scheduling of multiple time periods.
Sample rack compatibility specifications (SCR-DL-8 collector) : Up to 20 rows (8 samples per row), standard 1.5/2.0 mL HPLC/UPLC sample vial tray and 10 mL glass tube tray; equipped with automatic piercing needles, compatible with pre-compressed sealing gaskets.
Data storage and audit trail : Compliant with FDA 21 CFR Part 11, GMP/GLP, and ALCOA+ standards; built-in tamper-proof electronic audit trail (capable of storing up to 3 million records), original data files are tamper-proof, and complete PVT validation data and IQ/OQ validation documents are included as standard.
User access control : Hierarchical access control (four levels: operator, team leader, administrator, and original equipment engineer), supports 100 sets of account password logins or optional fingerprint scanner, and supports two-way network integration with the LIMS laboratory information management system.
External analysis and coupling expansion : Supports online ultraviolet spectrophotometry (UV-1900 + ADUV), online liquid chromatography (FC-1200 / SYP-1200 + ADLC), in-situ fiber optic continuous monitoring (Rainbow R6), 1-100x online automatic dilution, and coupling with the PERMETRO biomimetic membrane permeation system (IVIVC evaluation).
Image monitoring and remote management (optional) : Optional three-view camera system (bottom view, stirring axis, side view), supporting infrared imaging monitoring of sample scattering and coning in a darkroom; supports remote real-time monitoring and anomaly push notifications via smart mobile devices.
Equipment dimensions and power supply :
DSC-800 controller (including syringe pump): 12" × 15" × 24" (approximately 30 × 38 × 61 cm)
SCR-DL-8 Sample Collector: 19" × 22" × 19" (approx. 48 × 56 × 48 cm)
Main unit UDT-818-8: Approximately 65 × 54 × 66 cm
Power requirements: 110V / 220V, 50/60 Hz