Logan SYSTEM 918 (IVPT / IVRT) Dry Heat Fully Automated Transdermal Absorption System
The Logan 918-12 Transdermal Diffusion System is specifically designed for in vitro release (IVRT) and in vitro transdermal (IVPT) permeability studies of semi-solid formulations (ointments, creams, gels), transdermal patches, and cosmetics. This system fully complies with the United States Pharmacopeia (USP) <1724>, the European Pharmacopeia (EP), and US FDA/EMA regulations and guidelines for topical formulations and transdermal delivery systems.
I. 2×6 Dual-Row High-Throughput Vertical Diffusion Cell Design: Equipped with 12 vertical Franz Diffusion Cells in a 2×6 dual-row high-throughput architecture, supporting independent or simultaneous multi-batch sample comparison and parallel control experiments.
II. High-precision constant-temperature water bath circulation and micro magnetic stirring: The high-precision constant-temperature water bath circulation and micro magnetic stirring module ensure the uniformity of temperature (32°C ± 0.2°C or 37°C ± 0.2°C) and consistent rotation speed of the receiving liquid in each diffusion tank; the diffusion tank structure design, which facilitates the removal of bubbles, can effectively ensure the complete adhesion of the interface between biofilm or artificial membrane.
III. Modular automatic sampling and isothermal equal volume medium replenishment: It has excellent scalability and can be seamlessly upgraded and connected to automatic sampling robots and sample collection systems to achieve multi-point scheduled automatic sampling and real-time isothermal replenishment of media with equal volume.
IV. Strict Compliance and Data Integrity Management: The built-in intelligent control system fully supports an unalterable, full-function audit trail mechanism and multi-level user access control, fully complying with GMP/GLP and FDA 21 CFR Part 11 and ALCOA+ data integrity regulations.
Equipment Introduction
High-Throughput Transdermal Diffusion Platform
Dual-Row 12-Cell Layout : Equipped with 12 vertical Franz Diffusion Cells, supporting high-throughput simultaneous or parallel group experiments, significantly improving sample screening and detection efficiency.
Broad Formulation Versatility : Specifically designed for in vitro release (IVRT) and in vitro transdermal (IVPT) research of semi-solid formulations (ointments, creams, gels, lotions), transdermal patches, and various functional cosmetics.
Bubble-Free Cell Design : The exclusive Bubble-Free patent and bottom sampling optimized structure design ensure that the solvent replenishment equipment automatically removes bubble interference after each sampling, and the interface of both synthetic membranes and biofilms perfectly adheres to the receiving liquid without leakage.
Precision thermal control and magnetic stirring.
High-Precision Circulating Water Bath : Employs a highly efficient circulating heating water bath system to precisely maintain the temperature of the receiving liquid in each diffusion cell at physiological standards (32°C ± 0.2°C or 37°C ± 0.2°C), ensuring a highly consistent experimental environment.
Independent Synchronized Micro-Magnetic Stirring : Each diffusion cell base is equipped with a micro-magnetic stirring module with stable and uniform rotation speed, ensuring that the receiving medium is fully mixed without disrupting the diffusion dynamic balance.
Real-Time Temperature Monitoring : Built-in multi-point temperature sensors monitor the temperature status of the water bath and samples in real time, and have automatic alarm functions for over-temperature and abnormal conditions.
Fully automated sampling and isothermal media replacement.
Modular Robotic Sampling Upgrade : The system has excellent scalability and can be seamlessly connected to the Logan automated sampling arm and injection pump module to achieve fully automated sampling with multi-point preset scheduling.
Isothermal and Isothermal Media Replacement : After sampling, the system immediately and automatically replenishes an equal volume of preheated fresh receiving medium to maintain the liquid level and constant temperature in the diffusion cell and avoid dilution errors.
Automated Sample Collection & Storage : Automatically injects samples into standard HPLC/UPLC sample vials and supports low-temperature refrigeration trays to prevent volatilization and degradation, facilitating direct analysis.
Compliant with the International Pharmacopoeia and Data Integrity Compliance regulations.
Fully compliant with global regulations and pharmacopoeia guidelines : Fully compliant with all regulations and guidelines of the United States Pharmacopeia (USP) <1724>, the European Pharmacopeia (EP), and the US FDA/EMA for topical and transdermal drug delivery systems.
User-Friendly Intelligent GUI : A color touchscreen with a graphical user interface supports the storage and one-click recall of multiple experimental methods, with a clear and intuitive process.
Strict data integrity and audit trail compliance (21 CFR Part 11 & Audit Trail Compliance) : Built-in multi-level access control (multiple accounts and passwords) and an unalterable, fully functional audit trail mechanism, fully compliant with GMP/GLP and 21 CFR Part 11 data integrity requirements.
Product Features
Waterless dry heating
Patented automatic de-bubbling technology
Applicable to IVPT/IVRT
Overall Specifications
Number of diffusion cells : The standard configuration includes 12 vertical Franz diffusion cells, arranged in a 2×6 dual-row high-throughput matrix design, supporting simultaneous or grouped independent experiments.
Diffusion tank volume specifications : Standard sizes are 5.0 mL, 7.0 mL, and 12.0 mL (special sizes of 1.0 mL to 20.0 mL can be selected according to customer experimental needs).
Effective diffusion area : Standard aperture diffusion area is 0.64 cm² (Ø 9 mm) or 1.77 cm² (Ø 15 mm), and custom aperture specifications from 0.20 cm² to 3.14 cm² are also available.
Diffusion cell material and bubble removal design : Utilizing high-purity inert borosilicate glass and polyetheretherketone (PEEK), it is resistant to acid and alkali corrosion; featuring a patented bubble removal side tube design, it can quickly remove bubbles under the membrane after sample installation.
Applicable sample types and carriers : semi-solid formulations (ointments, creams, gels, lotions, clay masks), transdermal patches, microneedle patches, ophthalmic formulations, and various functional cosmetics.
Temperature control system architecture : An external high-efficiency circulating water bath with a double-layer insulated jacket water bath loop design ensures uniform temperature in the 12-hole diffusion tank.
Temperature control range : room temperature +5.0°C to 50.0°C
Temperature control accuracy : Temperature control accuracy reaches ±0.2°C (standard physiological body temperature 32.0°C ± 0.2°C and 37.0°C ± 0.2°C constant temperature control)
Magnetic stirring drive mechanism : Each diffusion tank is equipped with an independent micro magnetic stirring motor and Teflon magnetic stir bar at the bottom.
Stirring speed range and accuracy : Speed range 100 ~ 1,000 RPM (standard operating speed 300 ~ 600 RPM), speed control accuracy up to ±2.0 RPM.
Automated sampling robot integration : Optional upgrades include the Logan high-precision sampling arm and automated sample collection turntable module, supporting multi-schedule fully automated micro-sampling.
Sampling volume range and accuracy : Sampling volume range 0.10 mL ~ 5.00 mL, high-precision syringe pump sampling accuracy reaches ±1.0% or better than ±0.05 mL.
Isothermal and equal-volume automatic media replenishment : After sampling, the system immediately and accurately replenishes an equal volume of fresh receiving liquid to maintain a constant liquid level in the diffusion tank; the replenished fresh receiving medium is heated to the target temperature by the built-in preheating module to avoid temperature fluctuations in the tank caused by the introduction of cold liquid.
Sample collection tray specifications : Standard 1.5 mL / 2.0 mL HPLC/UPLC sample vial collection tray, supporting automatic collection at up to 12 wells × 12 sampling time points; optional low-temperature refrigeration tray (4°C ~ 10°C) to prevent sample degradation.
Color touchscreen interface : Color LCD touchscreen with graphical user interface; can store over 100 standard test methods.
International Pharmacopoeia Compatibility : Fully compliant with USP <1724> (Methods for Determination of Release Rate of Semi-solid Drugs), European Pharmacopoeia (EP), and US FDA/EMA testing specifications for IVRT/IVPT of topical preparations.
Access control and password protection : Features a multi-level access control system for administrators, supervisors, and operators, along with a secure password protection mechanism.
Audit Tracking and Data Integrity : Built-in full-featured, tamper-proof audit tracking records automatically record all operations, parameter changes, alarms, and correction events, complying with FDA 21 CFR Part 11 and cGMP/GLP Data Integrity (ALCOA+) regulations.