Logan SYSTEM 913 (IVPT / IVRT) Water Bath Automated Transdermal Diffusion System
The Logan 913-12 Automated Transdermal Diffusion Sampling System is specifically designed for in vitro release (IVRT) and in vitro transdermal (IVPT) permeability studies of semi-solid preparations (ointments, creams, gels), transdermal patches, and cosmetics. This system fully complies with the United States Pharmacopeia (USP) <1724>, the European Pharmacopeia (EP), and the US FDA/EMA regulations and guidelines for topical preparations and transdermal delivery systems.
I. Classic 12-station single-row vertical diffusion cell configuration: Equipped with 12 sets of vertical water bath double-layer jacketed Franz diffusion cells, specially designed for precise preparation and standard single-batch 12 control release experiments in R&D laboratories, combining high experimental flexibility with a compact footprint.
II. Precision water bath circulation constant temperature and micro magnetic stirring: The use of a precision double-layer circulating water bath jacket and micro magnetic stirring module ensures uniform temperature (32°C ± 0.2°C or 37°C ± 0.2°C) and consistent rotation speed of the receiving liquid in each diffusion tank; the patented diffusion tank structure design that facilitates the removal of bubbles can effectively ensure the complete adhesion of the interface between biofilm or artificial membrane.
III. Modular automatic sampling and isothermal equal volume medium replenishment: It has excellent expansion flexibility and can be seamlessly upgraded and connected to high-precision automatic sampling pumps and sample collection systems to achieve multi-point scheduling automatic sampling and real-time isothermal replenishment of media with equal volume.
IV. Strict Compliance and Data Integrity Management: The built-in intelligent control system fully supports an unalterable, full-featured audit trail mechanism and multi-level user access control, fully complying with GMP/GLP and FDA 21 CFR Part 11 and ALCOA+ data integrity regulations.
Equipment Introduction
High-Throughput Water-Jacketed Transdermal Diffusion Platform
Dual-Row 12-Cell Layout: The system consists of two standard 6-position diffusers connected in series, equipped with a total of 12 vertical water bath jacketed Franz Diffusion Cells, supporting high-throughput simultaneous or parallel control experiments of 12 samples.
Broad Formulation Versatility: Specifically designed for in vitro release (IVRT) and in vitro transdermal (IVPT) research of semi-solid formulations (ointments, creams, gels, lotions), transdermal patches, and functional cosmetics.
Patented Bubble-Free Cell Design: The diffusion cell features a patented bubble-free lateral sampling arm and angled flow guide structure, which can automatically and quickly expel bubbles during sampling and solvent replenishment, ensuring 100% tight adhesion between the synthetic membrane or biological tissue section and the receiving liquid without generating air resistance.
Precision Water-Jacketed Thermal Control & Magnetic Stirring
High-precision double-jacketed water circulation: The receiving chamber is covered with a precision double-jacketed circulating water circulation system, which accurately maintains the receiving liquid in each diffusion tank at the physiological temperature standard (32.0°C ± 0.2°C or 37.0°C ± 0.2°C), ensuring a uniform temperature field throughout the tank.
Independent Synchronized Micro-Magnetic Stirring: Each diffusion pool base is equipped with an independent micro-magnetic stirring module with a stable speed controlled between 100 and 1,000 RPM (±2.0 RPM), ensuring thorough mixing of the receiving medium and maintaining stable flow dynamics.
Multi-point real-time temperature monitoring and alarm (Real-Time Temperature Monitoring & Safety Cutoff): Built-in high-precision temperature sensor continuously monitors the water bath circulation and sample temperature status in real time, and has automatic audible and visual alarm protection for over-temperature, water shortage and abnormality.
Fully automated precision sampling and isothermal replacement system
High-Precision Multi-Channel Syringe Pump: Equipped with a precision bidirectional push-pull syringe pump (SYP series), the sampling range is 0.10 to 5.00 mL (accuracy better than ±1.0%), completely eliminating human error and time lag in manual sampling.
Isovolumetric & Isothermal Media Replacement: After each sampling, the system immediately replenishes the preheated solvent tank with an equal volume and isothermal fresh receiving medium to maintain a strict liquid level and sink condition in the diffusion tank.
Multi-Time-Point Automated Vial Collection: The DSC-800 sampling collector can automatically collect up to 12 time-point samples into standard HPLC/UPLC vials according to a set schedule. It can be equipped with an optional 4°C to 10°C low-temperature refrigeration tray to prevent trace samples from evaporating or degrading.
Complies with the International Pharmacopoeia and 21 CFR Part 11 Data Integrity Compliance.
Global Pharmacopoeia & Regulatory Compliance: Fully compliant with the United States Pharmacopeia (USP) <1724>, the European Pharmacopoeia (EP), and the review guidelines of the US FDA and European EMA for IVRT/IVPT systems for topical and transdermal drug delivery.
Intelligent Color Touchscreen GUI: Equipped with an industrial-grade color touchscreen, the operation process is clear and intuitive, and it can store more than 100 experimental methods, supporting one-click loading and scheduled execution.
Complete Audit Trail and Access Control (21 CFR Part 11 Audit Trail & User Security): Features multi-tiered user password access control, real-time electronic signatures, and tamper-proof complete audit trail records, fully compliant with FDA 21 CFR Part 11, cGMP/GLP, and ALCOA+ data integrity requirements.
Product Features
Precision water bath circulating constant temperature
Patented automatic de-bubbling technology
Applicable to IVPT/IVRT
Overall Specifications
Number of diffusion channels : Standard configuration includes 6 vertical Franz diffusion channels, using a 2×6 double-row precise independent arrangement design.
Diffusion tank volume specifications : Standard sizes are 5.0 mL, 7.0 mL, and 12.0 mL (special sizes of 1.0 mL to 20.0 mL can be selected according to customer experimental needs).
Effective diffusion area : Standard aperture diffusion area is 0.64 cm² (0.9 mm) or 1.77 cm² (0.15 mm), and custom aperture specifications from 0.20 cm² to 3.14 cm² are also available.
Diffusion cell material and bubble removal design : Utilizing high-purity inert borosilicate glass and polyetheretherketone (PEEK), it is resistant to acid and alkali corrosion; featuring a patented bubble removal side tube design, it can quickly remove bubbles under the membrane after sample installation.
Applicable sample types and carriers : semi-solid formulations (ointments, creams, gels, lotions, clay masks), transdermal patches, microneedle patches, ophthalmic formulations, and various functional cosmetics.
Temperature control system architecture : An external high-efficiency circulating water bath with a double-layer insulated jacket water bath loop design ensures uniform temperature in the 6-hole diffusion tank.
Temperature control range : room temperature +5.0°C to 50.0°C
Temperature control accuracy : Temperature control accuracy reaches ±0.2°C (standard physiological body temperature 32.0°C ± 0.2°C and 37.0°C ± 0.2°C constant temperature control)
Magnetic stirring drive mechanism : Each diffusion tank is equipped with an independent micro magnetic stirring motor and Teflon magnetic stir bar at the bottom.
Stirring speed range and accuracy : Speed range 100 ~ 1,000 RPM (standard operating speed 300 ~ 600 RPM), speed control accuracy up to ±2.0 RPM.
Automated sampling robot integration : Optional upgrades include the Logan high-precision sampling arm and automated sample collection turntable module, supporting multi-schedule fully automated micro-sampling.
Sampling volume range and accuracy : Sampling volume range 0.10 mL ~ 5.00 mL, high-precision syringe pump sampling accuracy reaches ±1.0% or better than ±0.05 mL.
Isothermal and equal-volume automatic media replenishment : After sampling, the system immediately and accurately replenishes an equal volume of fresh receiving liquid to maintain a constant liquid level in the diffusion tank; the replenished fresh receiving medium is heated to the target temperature by the built-in preheating module to avoid temperature fluctuations in the tank caused by the introduction of cold liquid.
Sample collection tray specifications : Standard 1.5 mL / 2.0 mL HPLC/UPLC sample vial collection tray, supporting automatic collection at up to 6 wells × 12 sampling time points; optional low-temperature refrigeration tray (4°C ~ 10°C) to prevent sample degradation.
Color touchscreen interface : Color LCD touchscreen with graphical user interface; can store over 100 standard test methods.
International Pharmacopoeia Compatibility : Fully compliant with USP <1724> (Methods for Determination of Release Rate of Semi-solid Drugs), European Pharmacopoeia (EP), and US FDA/EMA testing specifications for IVRT/IVPT of topical preparations.
Access control and password protection : Features a multi-level access control system for administrators, supervisors, and operators, along with a secure password protection mechanism.
Audit Tracking and Data Integrity : Built-in full-featured, tamper-proof audit tracking records automatically record all operations, parameter changes, alarms, and correction events, complying with FDA 21 CFR Part 11 and cGMP/GLP Data Integrity (ALCOA+) regulations.