The Logan Permeation Barrier Membrane (PBM) is a biomimetic artificial permeation barrier membrane designed specifically for screening new drug lead compounds, evaluating the in vitro permeability (IVPT) and in vitro release (IVRT) of poorly soluble formulations and transdermal/mucosal delivery systems. The product uses a high-mechanical-strength microporous permeable cellulose membrane as its structural matrix, tightly composited with multiple layers of biomimetic lipids to precisely mimic the passive mass transfer mechanism of the human stratum corneum and digestive tract epithelial cell membranes. This product is ready-to-use, overcoming all limitations of analyte polarity. It is seamlessly compatible with traditional Franz Cell, Side-by-Side Cell, and PERMETRO dissolution-osmosis systems, providing highly reproducible quantitative data for formulation development and in vitro-in vivo correlation (IVIVC) assessment.

I. Composite Matrix: High-strength microporous cellulose combined with a dense biomimetic lipid layer, resistant to stirring, erosion and pressure difference, eliminating lipid shedding, and specially designed for passive diffusion and rapid screening.

II. Broad Compatibility: Possesses polarity-independent diffusion properties, suitable for hydrophilic/lipophilic/amphoteric molecules; covers evaluation of poorly soluble BCS II/IV drugs, SMEDDS, ASD, nanospheres, semi-solid ointments and patches.

III. Dual Standard Disk Sizes: Available in Ø25.0 mm and Ø35.0 mm sizes, perfectly compatible with Logan 918-12 vertical Franz Cell, Side-by-Side horizontal cell and microfluidic fixtures, ensuring a tight, leak-proof installation.

IV. Flexible Temperature Control and Advanced Analysis: Supports temperature control from 25 to 37 ℃ (suitable for skin at 32 ℃ / physiological at 37 ℃) and custom sampling intervals; accurately measures cumulative amount, throughput (J) and Papp, and connects directly to HPLC/UPLC/LC-MS/MS/UV analysis.

V. Ready-to-use & Storage: No hydrolysis, cell culture, or TEER testing required; excellent data reproducibility (low %RSD); store at room temperature in a cool, dry place away from light (avoid UV exposure).

Product Introduction

• High-Strength Cellulose Membrane & Passive Mass Transfer Screening

  • It uses a microporous permeable cellulose membrane as the core physical support substrate, combined with a dense multilayer biomimetic lipid matrix, and is designed for rapid evaluation of passive mass transfer in new drug development, lead compound screening, and special formulations.

  • It possesses excellent mechanical tensile and shear strength, can withstand continuous stirring and flow environments, and has no risk of lipid layer shedding or rupture, providing drug molecules with a highly stable transmembrane passive diffusion channel.

• Overcoming polarity limitations in broad drug diffusion analysis (Polarity-Independent Diffusion & Broad Formulation Compatibility)

  • Diffusion and penetration analysis is completely independent of drug molecule polarity and can accurately measure the transmembrane penetration behavior of hydrophilic, lipophilic, and amphiphilic substances.

  • It is widely applicable to the evaluation of in vitro permeability (IVPT) and release (IVRT) of BCS Class II/IV poorly soluble drugs, supersaturated self-microemulsification systems (SMEDDS), amorphous solid dispersions (ASD), nanospheres, topical semi-solids (ointments, creams, gels) and transdermal patches.

• Standardized disk dimensions and versatile cell compatibility.

  • Available in two standard disk diameters: 25.0 ± 0.2 mm and 35.0 ± 0.2 mm. The non-porous mesh sieve structure (Pore Size: Not applicable) allows for precise matching with various test fixtures and diffusion cells.

  • Seamlessly compatible with conventional Franz cells, side-by-side cells, and various automated online and offline osmosis sampling test systems.

• Flexible operation temperature and freely selectable sampling intervals.

  • Supports a wide operating temperature range of 25℃～37℃, perfectly matching room temperature testing and human physiological body temperature (standard configuration 37.0 ± 0.2℃) constant temperature testing environment.

  • It supports freely selectable sampling intervals, allowing for flexible planning of multi-point or continuous sampling based on the dynamic release and penetration characteristics of the prescription, and accurately plotting the dynamic penetration kinetics curve of the drug.

• Comprehensive Permeation Metrics & Analytical Compatibility

  • It can accurately quantify and evaluate cumulative permeation, flux ( J ), apparent permeation coefficient ( P app), and drug recovery rate (Drug Recovery %).

  • The sample collection is fully compatible with mainstream chromatography and spectroscopic analysis platforms such as HPLC, UPLC, LC-MS/MS and UV-Vis spectrophotometry, ensuring high sensitivity and accuracy of data quantification.

• Ready-to-use, high reproducibility, and standard storage conditions.

  • Produced using standardized precision industrial processes, it is ready to use immediately (eliminating the need for pretreatment of ex vivo animal tissues, hydration culture, and transmembrane resistance (TEER) pre-test), completely eliminating individual differences in biological samples and providing highly reproducible data with extremely low %RSD.

  • Storage is simple; simply store in a dry environment at 25°C, away from light (do not expose to direct sunlight or ultraviolet (UV) radiation). Product warranty and expiration date are as indicated on the outer packaging label.