The Logan MDS-700 Multimedia Automated Addition/Replacement System is designed for automated pretreatment and media adjustment in dissolution tests. It can be connected to various dissolution analyzers and accurately performs automated media half-change and pH gradient switching for sustained-release, controlled-release, and enteric-coated formulations. This system fully complies with the testing specifications for delayed-release and enteric-coated formulations in the United States Pharmacopeia (USP) <711>, the European Pharmacopoeia (EP) <2.9.3>, and various national pharmacopoeias.

I. Designed specifically for two-stage dissolution testing (Acid Stage to Buffer Stage) of delayed-release and enteric-coated formulations. The system automatically and precisely dispenses preheated concentrated buffer at preset time points (e.g., automatically injecting 250 mL of concentrated buffer into 750 mL of 0.1 N HCl acidic medium to instantly prepare 1,000 mL of pH 6.8 buffer), realizing a seamless, fully automated dissolution process without human intervention.

II. Employing a multi-channel independent high-precision metering pump synchronous dispensing design, the dispensing volume accuracy reaches within ±1.0%. This ensures synchronized and uniform dispensing height in each dissolution vessel, completely eliminating time delays, volume deviations, and cross-contamination risks associated with manual addition, significantly improving batch repeatability and test reliability.

III. Equipped with an independent constant-temperature preheating bath and insulated transmission pipeline, the buffer solution is precisely preheated to the standard physiological temperature (37.0 ± 0.5 °C) before injection. This effectively eliminates the thermal shock caused by traditional injection of cold media, ensuring that the drug release rate is not affected by thermal effects and strictly complies with USP/EP specifications.

IV. The control system is equipped with multi-level user access management that complies with regulations and an tamper-proof, full-featured electronic audit trail, which records operation events, liquid addition time stamps and parameter changes in real time, fully complying with cGMP/GLP, FDA 21 CFR Part 11 and ALCOA+ data integrity requirements.

Equipment Introduction

• High-Efficiency Dispensing & Precision Dosing System

  • Rapid Multi-Vessel Synchronized Dispensing : Equipped with a large, high-precision syringe pump, the dispensing volume ranges from 250 to 2000 mL, and it can simultaneously dispense 6 cups of 1L dissolution medium in less than 2 minutes.

  • High Volumetric Accuracy : Volumetric accuracy for media of 250 mL and above is ≥ 99.0%, completely eliminating errors from manual dispensing and cumbersome measurement procedures.

  • Hands-Free Dispensing & Flexible Top-Up Gun : Equipped with a hands-free dispensing manifold and an independent single-port top-up gun, it allows for easy and precise top-up. The system supports automatic bleed and pre-lubrication functions.

• Superior Deaeration & Precision Thermal Control

  • Strict Deaeration & Low DO Level Control : Ensures high consistency of deaeration between dissolution vessels, and maintains a stable dissolved oxygen level (DO level) of < 6 ppm after deaeration. It features a built-in 45 µm filtration system and fully complies with USP Toolkit and PVT guidelines.

  • Rapid Pre-Heating & Precise Temperature Control : The ambient temperature can be heated to 37°C in less than 25 minutes, and the temperature control accuracy is ±0.3°C, avoiding temperature fluctuations in the dissolution vessel caused by the injection of cold media.

• Large-capacity, zero-dead-volume tank with broad compatibility.

  • 40L Large Capacity Dedicated Trolley Tank (40L Zero-Dead-Volume Mobile Tank) : Adopting a zero-dead-volume (0.00 L) design, equipped with a modular quick-change mechanism, it is convenient to change tanks by yourself and is suitable for different media. Dedicated tanks completely avoid cross-contamination.

  • Surfactant & Multi-Brand Instrument Compatibility : Compatible with surfactant media up to 2% SLS; not only designed specifically for LOGAN dissolution testers, but also widely compatible with dissolution testers from major brands such as Agilent, Hanson, and Distek.

  • Excellent mobility and space optimization:

    Featuring an independent floor-standing mobile trolley design, the system fully preserves the valuable laboratory tabletop, providing operators with ample working space or meeting the specific positioning needs of various precision analytical equipment . The system comes with a 40L dedicated trolley container and a 7.3m extra-long power cord, supporting 110V/220V power input, and offers great flexibility in moving around the laboratory and supporting cross-machine and cross-group operations.

• 8-Position Dissolution Vessel Carrier & Positioning Rack

  • MDS-700 Batch Dispensing: Seamless Pairing

    With a precise 4×2 spacing configuration, it can stably place 6 to 8 standard 1000 mL dissolution cups at a time; it works perfectly with the MDS-700 multi-channel dispensing manifold for batch positioning, enabling high-precision temperature-controlled and degassed solvent filling of 6–8 cups in one go, significantly reducing pre-processing time.

  • Safe and efficient transport line (Safe & Spill-Free Transport to Cleaning Station):

    After the experiment is completed, the operator no longer needs to handle the fragile glass cups one by one. With the ergonomic handles on both sides, the entire batch (up to 8 cups) can be extracted smoothly and directly transferred to the washing tank, ultrasonic vibrator or drying area, completely eliminating the industrial safety risk of a single cup slipping and breaking and the possibility of liquid spillage.

  • Durable and chemically resistant design:

    The main body is made of a chemically resistant composite material with high rigidity, resistance to acids and alkalis and surfactants. The double-layer perforated skeleton provides vertical coverage of the cup body and excellent anti-shake protection. The bottom is equipped with highly stable non-slip feet, which can stand firmly on the laboratory table, trolley or washing sink.

  • Extensive compatibility with multiple brands of dissolution vessels (Universal Vessel Compatibility):

    The aperture and cup body positioning groove are precisely molded, making it fully compatible with standard 1000 mL glass dissolution cups (including round bottom, flat bottom and rimmed/unrimmed models) from major brands such as LOGAN, Agilent, Hanson, Distek, Pharma Test, and Sotax.

• Intelligent and intuitive operation, comprehensive data security and report output (Intuitive UI, Data Integrity & Report Management)

  • Intuitive Wizard-Driven Workflow : The entire process, from "login verification → selecting method for preheating → recording dissolution instrument serial number → starting simultaneous dispensing of 6 cups," is automatically recorded via a large touchscreen, making operation intuitive and effortless.

  • Strict regulations and full-chain traceability (21 CFR Part 11 Compliance & Traceability) : Compliant with 21 CFR Part 11, providing unlimited capacity audit trails, unlimited user and group customization, configurable password policies, and full-chain device serial number traceability (dissolution meter/DO meter/pH meter).

  • Convenient Report Storage & Printing : Built-in memory can store the 100 most recent complete records, supporting on-demand printing to embedded thermal printers or network A4 printers.

Interface Introduction

• Intuitive Touchscreen UI & Standardized Dispense Workflow

  • Four-Step Wizard Dispense Workflow : Through a large-screen color touchscreen, follow the standard procedure of "1. Account login and verification ➔ 2. Select method and preheat ➔ 3. Record dispensing instrument SN ➔ 4. Start simultaneous dispensing of 6 cups", which greatly reduces the complexity of operation and human error.

  • Intuitive status monitoring and one-touch start : The main screen clearly displays the current temperature (e.g., 23.6°C / target 37.0°C), volume distribution, vacuum degassing status, and circulation/heater switch, and provides a prominent START button and Auto/Manual mode switching.

  • Built-in multiple preset volumes and custom methods (Pre-saved Volumes & Unlimited Method Storage) : Pre-set shortcut keys for commonly used dissolution volumes of 250, 500, 750, 900, and 1000 mL, and supports storage and quick loading of an unlimited number of custom methods from 250 to 2000 mL.

• Strict user access control and security policies (Advanced User Management & Security Policies)

  • Unlimited Users & Customizable Security Groups : Supports an unlimited number of users and custom security groups (such as Admin and general groups), with specific detailed permissions for user creation, editing, deactivation, method import/export, and audit tracking printing.

  • Fully Configurable Password Security Rules : Supports password lengths of 4 to 32 characters, character complexity (uppercase/lowercase/numbers/special characters), regular update cycles, automatic locking after login failures, screen privacy lock time, and advanced settings such as prohibiting consecutive characters, fully complying with enterprise IT security policies.

  • USB & Ethernet Interface Security Control : The system provides dedicated USB and Ethernet connection enable/disable switches to strictly control external storage devices and network data transmission, effectively eliminating the risk of unauthorized access.

• Complete data integrity and end-to-end equipment traceability (21 CFR Part 11 Compliance & Complete Traceability)

  • Unlimited Audit Trail with Smart Filtering : The software fully complies with 21 CFR Part 11, recording all processes including user login, method selection, parameter changes, and system power-on/off in a complete and immutable manner. It also provides quick search/filtering by date range and keywords, as well as PDF export.

  • End-to-End Instrument Serial Number Traceability: Before operation, the corresponding serial numbers of the dissolution ionizer, dissolved oxygen meter (DO Meter) and pH meter (pH Meter) can be recorded manually or automatically, realizing complete traceability of the entire life cycle of analytical experimental data.

  • Automatic Storage of Recent 100 Run Reports : The system automatically remembers and stores the latest 100 detailed run records (including allocated volume, heating temperature, vacuum status, operator, and completion time), which can be viewed and reviewed at any time.

• Flexible and diverse report output and printer selection management.

  • Built-in Thermal & Network A4/Letter Printer Support : The system has a built-in printer selection and connection management interface, which allows you to freely switch between the built-in thermal printer or the A4/Letter printer in the local area network (such as EPSON network printers).

  • On-Demand Detailed Report Printing : Supports on-demand printing of historical records, audit tracks, security group settings, and method parameters, providing dual compliance evidence in both paper and digital formats.