Logan's biomimetic membranes for drug absorption are specifically designed for integrated dissolution-permeation evaluation and development of transdermal drug delivery systems (TDDS), intravenous transdermal drug delivery systems (IVPT/IVRT) for semi-solid topical preparations, and oral solid preparations (BCS II/IV class poorly soluble drugs, SMEDDS). The product perfectly integrates patented liposome matrix synthesis technology with a high-mechanical-strength supporting membrane, accurately mimicking the passive diffusion barrier of the human skin's stratum corneum and gastrointestinal epithelial mucosa. This product fully complies with the stringent standards of various pharmacopoeias (USP <1724>, USP <711>, EP, EMA, and FDA) for in vitro biorelevance penetration testing, completely eliminating the donor variation and ethical limitations of traditional animal and human skin. It is an indispensable core consumable and predictive tool for connecting downstream vertical Franz Diffusion Cells and Permetro dissolution-osmosis systems.

I. Biomimetic Barrier & IVIVC Correlation: The multi-layered biomimetic lipid structure highly replicates the stratum corneum and intestinal mucosa, accurately quantifying Flux and cumulative permeation, significantly improving the accuracy of IVIVC and BE prediction for poorly soluble drugs.

II. Superior Chemical Stability and Media Tolerance: Tolerates pH gradient switching (FaSSIF/FeSSIF) and high concentrations of surfactants (SDS/Tween 80) from 1.0 to 8.0, maintaining barrier integrity for more than 4 to 24 hours without the risk of erosion or leakage.

III. Industrial Standardized Production and Extreme Reproducibility: Precision coating processes ensure uniform film thickness and micropores, eliminating 30%–50% data divergence in biological tissues (ultra-low %RSD), and eliminating IRB/IACUC ethical review and biohazards.

IV. Ready-to-Use & Ambient Storage: Open the bag and fill immediately, eliminating the need for tedious pre-processing such as thawing, degreasing, hydration, and TER pre-testing; supports room temperature dry storage, freeing you from the limitations of the -20°C/-80°C cold chain.

V. Modular Seamless System Integration: Perfectly compatible with Logan System 918-12 Vertical Franz Cell (IVRT/IVPT) and can be embedded in Logan's patented 6-well Permetro flow cell, connecting to USP 1-7 dissolution analyzers and DSC-800 to achieve real-time fully automated dissolution-permeation.

Product Introduction

• Membrane Structure & Type : Patented biomimetic lipid-based artificial membrane, combining a high-mechanical-strength microporous support substrate with a biomimetic bilayer of lipids.

• Biological Barrier Simulation Capability : Provides a dual simulation series of the stratum corneum and gastrointestinal epithelial mucosa (GI Tract/Oral Epithelial Barrier), which highly simulates the human body's passive diffusion and paracellular transport and absorption mechanisms.

• Primary Application Fields : Suitable for penetration and absorption screening of poorly soluble drugs (BCS Class II/IV), self-microemulsifying drug delivery systems (SMEDDS), nano suspensions, transdermal absorption patches (TDDS), topical semi-solid preparations (IVPT/IVRT), and oral mucosal delivery systems.

• Surfactant and Solvent Chemical Resistance: It has high chemical stability and can withstand common surfactants (such as SDS/SLS, Tween 80, Triton X-100, Brij, etc.) and aqueous/organic co-solvents. No membrane rupture or leakage occurs after continuous testing for 4 to 24 hours or more.

• pH Range & Biorelevant Media Compatibility : Applicable to a wide pH range of 1.0 to 8.0; fully compatible with artificial gastric juice (SGF), artificial intestinal juice (SIF), fasting/full biorelevant media (FaSSGF, FaSSIF, FeSSIF) and bile salt complex media.

• Instrument System Compatibility : Fully compatible with Logan System 918-12 vertical Franz diffusion cell (USP <1724>), Permetro dissolution-penetration integrated microfluidic cell (compatible with USP 1, 2, 3, 4, 7 methods), Side-by-Side diffusion cell, and standard high-throughput microwell plate.

• Ready-to-Use Characteristics : Completely standardized from the factory, requiring no hydration, no pretreatment of animal tissues such as scraping/hair removal, and no pre-screening by membrane resistance (TEER), significantly reducing experimental preparation time.

• Data Reproducibility & Quality Control : Standardized chemical manufacturing process, with extremely low intra-batch and inter-batch flux variation coefficients (%RSD significantly better than traditional animal ex vivo skin and Caco-2 cell lines), effectively eliminating individual biological differences.

• Biosafety & Ethical Compliance : Non-animal-derived synthetic materials, completely exempt from IRB/IACUC animal ethics review procedures and potential biohazard infection risks.

• Storage and Preservation Conditions : Store at room temperature in a dry, dark place (no need for -20°C or -80°C ultra-low temperature refrigeration equipment). It has good chemical stability at room temperature and a long shelf life.

• Regulatory & Technical Guidelines Compliance : Complies with the technical guidelines of the US FDA and EMA regarding drug penetration testing (IVPT/IVRT) and in vitro-in vivo correlation (IVIVC) predictive assessment.

• Dimensional Specifications & Sizing Compatibility : Standard diameter specifications (such as 25 mm, 35 mm circular diaphragms and continuous sheets) are available, which can be directly adapted to various standard diffusion cell clamps.