CambTEK SPE Sample Extraction System
The CambTEK SPEx Solid Preparation and Extraction System is designed for pharmaceutical R&D, high-throughput quality control (QC) and API/formulation analysis laboratories. It can be used for fully automated sample pulverization, homogenization, solvent addition and online filtration of tablets, capsules, powders, granules, semi-solids and various high-matrix solid dosage forms.
I. Adopting a revolutionary single-use sealed extraction bag design, the entire process of sample crushing, extraction and filtration is completed in one step, completely eliminating the traditional glassware cleaning operation and achieving "zero cross-contamination" and ultimate data reproducibility between samples.
II. Equipped with a high-torque, high-speed shear homogenizer and a precise solvent automatic addition module, it can quickly pulverize high-hardness tablets, controlled-release formulations (SR/CR/OROS), and high-viscosity matrices (HPMC/PEG) within minutes, ensuring 100% complete extraction and release of active ingredients (APIs).
III. Built-in online micron-level precision filtration system (0.2 µm / 0.45 µm), after extraction, it can be directly dispensed into standard HPLC / UPLC / UV sample vials, reducing the overall sample pretreatment time by up to 70% compared to traditional manual grinding and ultrasonic vibration.
IV. The ultra-compact desktop unit (only 12 kg) features an independent embedded color touchscreen that can operate autonomously without an external computer; the closed extraction environment effectively protects against exposure to high-potency APIs and fully complies with GMP, GLP, and 21 CFR Part 11 data integrity regulations.
Equipment Introduction
Patented High Frequency Pulverizing Technology
Disrupting physical structure to maximize surface area : It can quickly pulverize solid samples into fine powder with uniform particle size, creating optimal conditions for subsequent solvent extraction.
Overcomes the limitations of high-difficulty samples : Effectively handles extremely high hardness, special coating formulations, or laser-drilled tablets (OROS).
Patented Forced Jet Mixing technology
High-speed fluid circulation and strong turbulence : High-pressure jetting is used to achieve efficient fluid circulation within the container, completely eliminating concentration gradients and ensuring 100% homogenization and representativeness of the sample.
Achieve 100% dissolution of active ingredients (APIs) : Significantly shortens the dissolution time of poorly soluble matrices compared to traditional stirring.
Patented Single-Use Extraction Pouch Design
Containers are converted into consumables (use and discard) : single-use special pressure-resistant polymer bags completely eliminate cross-contamination between samples.
Eliminate Cleaning Validation : Eliminate the most cumbersome, time-consuming, and non-value-adding costs associated with cleaning and validating glassware in pharmaceutical regulations.
Built-in functional zones and flexible capacity : Available in 25–100 mL and 100–500 mL sizes, with dedicated grinding and mixing zones inside.
Automated Precision Solvent Dispensing System
High repeatability and precise volume control : Built-in precision liquid transfer pump eliminates human error from manual measuring cylinders or pipette measurements.
Significantly reduces organic solvent consumption and exposure : The closed-loop automatic dispensing system reduces solvent usage by more than 50% compared to traditional large-volume flask extraction.
In-line integrated microfiltration (HPLC Vials)
Integrated automated sample filtration : The extract can be directly transferred to HPLC/UPLC sample vials by passing it directly through a standard 0.2 µm or 0.45 µm injection filter membrane.
Eliminates manual filtration steps : Eliminates repetitive operational injury (RSI) from manual syringe filtration and eliminates errors caused by membrane adsorption or operational differences.
Intuitive touchscreen operation and modern data interface (Intuitive Touchscreen & USB Export)
Standalone Unit : A full-color touchscreen paired with an embedded system provides intuitive operation and can run independently without the need for a bulky external computer.
Standardized method storage and data export : Supports quick access to multiple custom extraction methods and can export runtime logs and reports via USB port to meet laboratory recording standards.
Product Features
Patented high-frequency pulverizing technology
High-powered spray mixing technology
Disposable patented extraction bag
Overall Specifications and Advantages
Reduce processing time by 70% : Integrating automatic crushing, rapid homogenization, and no-cleaning mechanisms significantly reduces overall pre-processing turnaround time.
A standardized six-step process : Intuitive "Preparation (bag insertion/sample addition) ➔ Execution (automatic procedure) ➔ Completion (liquid collection/disposal)" reduces operational difficulty and personnel training costs.
Eliminating human error : Comprehensive standardization of sample pretreatment eliminates differences in operating techniques, ensuring high reproducibility and consistency of data across batches.
Solid dosage form compatibility : Supports general tablets, sustained-release tablets (SR), osmosis pump laser-drilled tablets (OROS), hard/soft capsules, sublingual tablets, powders, and granules.
Semi-solid and liquid compatibility : Supports high-viscosity gels, suppositories, intermediate granules, and various liquid formulations.
Treatment of excipients for poorly soluble formulations : Fully stabilized high-viscosity and slow-release polymer matrices such as HPMC, PEG, and PEO.
Solvent compatibility and downstream bonding : Compatible with aqueous phases and various polar/non-polar organic solvent systems, the extract can be directly and seamlessly bonded to precision analytical instruments such as HPLC, UPLC, and UV-Vis.
Reduced operating costs : Optimized solvent consumption eliminates glassware breakage and the costs of tedious manual cleaning supplies and time.
Compliance (Data Integrity) : The no-clean/fully enclosed mechanism eliminates the risk of cross-contamination, fully complying with GMP, GLP, and 21 CFR Part 11 requirements.
EHS Occupational Safety and Health : A fully enclosed sample extraction environment eliminates the risk of personnel exposure to volatile organic solvents (VOCs) or high-potency active pharmaceutical ingredients (HPAPIs).
Extremely compact desktop design : Dimensions are 302 mm × 313 mm × 510 mm, and it weighs only 12 kg. It can be placed directly in a fume hood or on a laboratory workbench for operation.
Independent intelligent control system : Built-in embedded firmware and operating screen, enabling method editing, program calling, and independent automated operation without the need for an external computer.
Universal voltage : Supports 100–240 VAC universal voltage, featuring low power consumption and high environmental adaptability.